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KMID : 0375319940160010089
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Journal of Clinical Pathology and Quality Control
1994 Volume.16 No. 1 p.89 ~ p.96
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The Effect of Red ginseng on Platelet Aggregation in Noninsulin-dependent Diabetes Mellitus Patients
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Abstract
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Background:
Diabetes mellitus accelerates atherosclerosis and predisposes to specific microvascular problems. Many studies have been attempted to illustrate the role of platelets in the development of vascular complications.
Methods:
The effect of red ginseng on platelet aggregation, in this study, was investigated in 30 noninsulin-dependent diabetes mellitus(NIDDM) patients for 5 months, and who were divided into two groups; 1) administration of oral hypoglycemic drug only
(the
control group), and 2) administration of oral hypoglycemic drug and 4.5g of red ginseng daily (the ginseng group).
Results:
The threshold concentration of ADP to initiate second phase aggregation was higher in the ginseng group than in the control group (3.6 μM vs. 2.4μM; p=0.009). Among the ginseng group, the mean threshold concentrations of ADP and
epinephrine-induced aggregation were significantly increased (ADP p=0.014, epinephrine p=0.043) after treatment for 20 weeks. The mean threshold concentration of collagen-induced aggregation is significantly increased after treatment for 16 weeks
in
both groups. No significant changes could be demonstrated in platelet number in both groups.
Conclusions:
Treatment of NIDDM patients with oral hypoglycemic drug in combination with red ginseng showed a more favorable effect on the platelet dysfunction and ginseng may be useful as a therapeutic adjuvant to preventing chronic vascular complication
in
NIDDM patients.
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